# Original dataframe df:
Fruit   Date      Name  Number
Apples  10/6/2016 Bob    7
Apples  10/6/2016 Bob    8
Apples  10/6/2016 Mike   9
Apples  10/7/2016 Steve 10
Apples  10/7/2016 Bob    1
Oranges 10/7/2016 Bob    2
Oranges 10/6/2016 Tom   15
Oranges 10/6/2016 Mike  57
Oranges 10/6/2016 Bob   65
Oranges 10/7/2016 Tony   1
Grapes  10/7/2016 Bob    1
Grapes  10/7/2016 Tom   87
Grapes  10/7/2016 Bob   22
Grapes  10/7/2016 Bob   12
Grapes  10/7/2016 Tony  15

df.groupby(['Fruit','Name']).sum() # Use .groupby().sum()

#Output:                
Fruit   Name    Number     
Apples  Bob        16
        Mike        9
        Steve      10
Grapes  Bob        35
        Tom        87
        Tony       15
Oranges Bob        67
        Mike       57
        Tom        15
        Tony        1