var object = { 'a': [{ 'b': { 'c': 3 } }] };
 
_.set(object, 'a[0].b.c', 4);
console.log(object.a[0].b.c);
// => 4
 
_.set(object, ['x', '0', 'y', 'z'], 5);
console.log(object.x[0].y.z);
// => 5