#Problematic code:   answer = input("Is it", guess, "?")

#input only accepts one argument, you are passing it 3. You need to use string 
#formatting or concatenation to make it one argument:

answer = input("Is it {} ?".format(guess))

#You were confusing this with the print() function, which does indeed take more 
#than one argument and will concatenate the values into one string for you.