In [39]:

df['2nd'] = df['2nd'].str.replace(',','').astype(int)
df['CTR'] = df['CTR'].str.replace('%','').astype(np.float64)
df.dtypes
Out[39]:
Date         object
WD            int64
Manpower    float64
2nd           int32
CTR         float64
2ndU        float64
T1            int64
T2            int64
T3            int64
T4           object
dtype: object
In [40]:

df.head()
Out[40]:
        Date  WD  Manpower   2nd   CTR  2ndU   T1  　　T2   T3     T4
0   2013/4/6   6       NaN  2645  5.27  0.29  407   533  454    368
1   2013/4/7   7       NaN  2118  5.89  0.31  257   659  583    369
2  2013/4/13   6       NaN  2470  5.38  0.29  354   531  473  　　383
3  2013/4/14   7       NaN  2033  6.77  0.37  396   748  681    458
4  2013/4/20   6       NaN  2690  5.38  0.29  361   528  541    381