$args = array(
    'post_type' => 'post',
    'tax_query' => array(
        'relation' => 'AND',
        array(
            'taxonomy' => 'movie_genre',
            'field'    => 'slug',
            'terms'    => array( 'action', 'comedy' ),
        ),
        array(
            'taxonomy' => 'actor',
            'field'    => 'term_id',
            'terms'    => array( 103, 115, 206 ),
            'operator' => 'NOT IN',
        ),
    ),
);
$query = new WP_Query( $args );