Memory consumption: Glide occupies less memory as compared to Picasso. Reason being is Picasso loads full images doesn't matter what ImageView dimensions are mentioned, where as Glide loads image from server for the ImageView size (height/width)
Library size: Glide is heavier in terms of library size as compared to Picasso.
Number of methods: Glide is having more number of methods as compared to Picasso.
GIF Support: Picasso doesn't support GIF image loading.