# Will return rows with 1 or 6 in colA and 'yourValue' in colB
YourModel.objects.filter(colA__in=[1,8],colB='yourValue')

# Will return rows with 1 or 6 in colA OR
# potentially different rows with 'yourValue' in colB
YourModel.objects.filter(colA__in=[1,8]).filter(colB='yourValue')