>>> f = open('workfile', 'rb+')
>>> f.write(b'0123456789abcdef')
16
>>> f.seek(5)      # Go to the 6th byte in the file
5
>>> f.read(1)
b'5'
>>> f.seek(-3, 2)  # Go to the 3rd byte before the end
13
>>> f.read(1)
b'd'