>>> df1 = pd.DataFrame([["AAA", "BBB"]], columns=["Spam", "Egg"])
>>> df2 = pd.DataFrame([["ABC", "XYZ"]], columns=["Foo", "Bar"])
>>> with ExcelWriter("path_to_file.xlsx") as writer:
...     df1.to_excel(writer, sheet_name="Sheet1")
...     df2.to_excel(writer, sheet_name="Sheet2")