DirectoryEntry rootEntry = new DirectoryEntry("LDAP://dc=yourcompany,dc=com");

DirectorySearcher srch = new DirectorySearcher(rootEntry);
srch.SearchScope = SearchScope.Subtree;

srch.Filter = "(&(objectClass=user)(sAMAccountName=yourusername)(memberOf=CN=yourgroup,OU=yourOU,DC=yourcompany,DC=com))";

SearchResultCollection res = srch.FindAll();

if(res == null || res.Count <= 0) {
    Console.WriteLine("This user is *NOT* member of that group");
} else {
    Console.WriteLine("This user is INDEED a member of that group");
}