mysql> select table_schema, sum((data_length+index_length)/1024/1024) AS MB from information_schema.tables group by 1;
+--------------------+-----------------+
| table_schema       | MB              |
+--------------------+-----------------+
| prod               | 298025.72448921 |
| information_schema |      0.00781248 |
| maatkit            |     70.77330779 |
| mysql              |      0.66873168 |
| test               |   4752.31449127 |
+--------------------+-----------------+
5 rows in set (0.01 sec)