RewriteEngine on
RewriteCond %{HTTP_HOST} ^(www.)?example.com$
RewriteCond %{REQUEST_URI} !^/my_subdir/
RewriteCond %{REQUEST_FILENAME} !-f
RewriteCond %{REQUEST_FILENAME} !-d
RewriteRule ^(.*)$ /my_subdir/$1
RewriteCond %{HTTP_HOST} ^(www.)?example.com$
RewriteRule ^(/)?$ my_subdir/index.php [L]