' Sorts a range with multiple criterias
Sub MultipleColumnsSort()
    With ActiveSheet.Sort
         .SetRange Range("A1:D10")
         .SortFields.Add Key:=Range("A1"), Order:=xlAscending
         .SortFields.Add Key:=Range("B1"), Order:=xlDescending
         ' If range includes headers
         .Header = xlYes
         .Apply
    End With
End Sub