import pandas as pd

data = {'spike-2': [1,2,3], 'hey spke': [4,5,6], 'spiked-in': [7,8,9], 'no': [10,11,12]}
df = pd.DataFrame(data)

spike_cols = [col for col in df.columns if 'spike' in col]
print(list(df.columns))
print(spike_cols)