pd.DataFrame({"A": [1, 2], "B": [3, 4]}).to_numpy()
array([[1, 3],
       [2, 4]])
       
       
data = np.array([['','Col1','Col2'],
                ['Row1',1,2],
                ['Row2',3,4]])
                
print(pd.DataFrame(data=data[1:,1:],
                  index=data[1:,0],
                  columns=data[0,1:]))