import hmac
import hashlib
import base64
dig = hmac.new(b'1234567890', msg=your_bytes_string, digestmod=hashlib.sha256).digest()
base64.b64encode(dig).decode()      # py3k-mode
'Nace+U3Az4OhN7tISqgs1vdLBHBEijWcBeCqL5xN9xg='