import pandas as pd

# Example DataFrame
df = pd.DataFrame.from_dict({'Name'  : ['May21', 'James', 'Adi22', 'Hello', 'Girl90'],
                             'Volume': [23, 12, 11, 34, 56],
                             'Value' : [21321, 12311, 4435, 32454, 654654]})

df['Name'] = df['Name'].str.replace('\d+', '')

print(df)