from PIL import Image

with Image.open("hopper.jpg") as im:

    # The crop method from the Image module takes four coordinates as input.
    # The right can also be represented as (left+width)
    # and lower can be represented as (upper+height).
    (left, upper, right, lower) = (20, 20, 100, 100)

    # Here the image "im" is cropped and assigned to new variable im_crop
    im_crop = im.crop((left, upper, right, lower))